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Zeptide 5mg/0.5ml Pre-filled Syringe
- Tirzepatide is prescribed alongside diet and exercise to:
- Improve blood sugar control in adults with type 2 diabetes
- Aid weight management by reducing appetite and supporting weight loss when paired with a healthy lifestyle
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✅ Description:
- Type 2 Diabetes Mellitus: Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.
- Weight Management: Indicated for chronic weight management in adults with obesity or overweight and at least one weight-related condition (e.g., hypertension, type 2 diabetes, or dyslipidemia).
- Obstructive Sleep Apnea (OSA): Used in patients with obesity-related moderate to severe OSA to support weight reduction and improve sleep-disordered breathing.
Tirzepatide is a dual agonist of GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors. It enhances glucose-dependent insulin secretion, suppresses glucagon secretion, delays gastric emptying, and promotes satiety. These actions collectively contribute to improved glycemic control and weight reduction.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses
Treat type 2 diabetes
✔️ Dosage & Administration
Initial Dose:
Start with 2.5 mg subcutaneously once weekly for 4 weeks.
Titration: Increase by 2.5 mg increments every 4 weeks as tolerated.
Maximum dose: 15 mg once weekly.
Administration Instructions:
- Inject under the skin (subcutaneously) in the abdomen, thigh, or upper arm.
- Rotate injection sites to avoid lipodystrophy.
- Administer on the same day each week, with or without meals.
- Inspect the solution for clarity; discard if discolored or contains particles.
- Use a new needle for each injection. Never share pens.
Missed Dose:
If a dose is missed, administer within 4 days. If more than 4 days have passed, skip and resume the regular schedule.
✔️ Adverse Effects of
Common:
- Nausea, vomiting, diarrhea
- Abdominal pain
- Injection site reactions
- Loss of appetite
Serious:
- Pancreatitis
- Thyroid tumors
- Acute kidney injury
- Gallbladder disease (e.g., cholelithiasis, cholecystitis)
- Hypoglycemia (especially with insulin/sulfonylureas)
- Diabetic retinopathy
- Severe allergic reactions (e.g., anaphylaxis, angioedema)
- Behavioral changes, suicidal thoughts
✔️ Drug Interactions
Avoid or Use with Caution:
Hormonal Contraceptives (e.g., Desogestrel, Drospirenone, Levonorgestrel)
Tirzepatide may reduce oral contraceptive efficacy.
Warfarin
May alter INR; monitor closely.
Other Antidiabetics:
Risk of hypoglycemia when used with sulfonylureas or insulin. Monitor glucose levels and adjust dose if needed.
Other Interactions
Alcohol: Increases risk of hypoglycemia.
Food: Can be administered with or without food.
Smoking: No specific interactions documented, but lifestyle factors may impact glycemic control.
✔️ Use in Special Populations
- Pediatric: Safety and efficacy not established.
- Geriatric: No age-related restrictions, but elderly patients may be more sensitive.
- Pregnancy: Avoid use. Discontinue at least 2 months before planned conception (especially with Mounjaro®). Zepbound® may pose fetal risks.
- Breastfeeding: Data is insufficient; use only if benefits outweigh risks.
✔️ Contraindications
- Personal or family history of medullary thyroid carcinoma (MTC)
- Patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
- Severe gastroparesis
- Type 1 diabetes mellitus
✔️ Precautions
- Monitor thyroid health. Report neck masses, hoarseness, or dysphagia.
- Use cautiously in patients with pancreatitis, retinopathy, renal impairment, or depression.
- May delay gastric emptying—inform the surgeon before procedures involving anesthesia.
- Advise contraception adjustment if using oral contraceptives—efficacy may be reduced.
✔️ Monitoring & Follow-Up
- Monitor blood glucose levels regularly.
- Assess renal function, vision (for diabetic retinopathy), and thyroid health.
- Perform routine follow-up labs for liver and pancreatic enzymes.
✔️ Storage Instructions
- Store in the refrigerator (2–8°C). Do not freeze.
- Once removed from the fridge, it may be stored at room temp (up to 30°C) for 21 days.
- Do not refreeze after it has reached room temperature.
- Discard used pens and needles safely in a puncture-resistant container.
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